Some of the most common symptoms and features reported across literature and research, about symptoms experienced by those with GRIN2A include:

• Seizures: which often begin in early childhood, but ranges from shortly after birth to later in childhood. Some people never develop epilepsy. Epilepsy types include focal epilepsies, epileptic encephalopathies such as Landau-Kleffner Syndrome (LKS) and Continuous Spike and Wave During Sleep (CSWS); childhood epilepsy with centrotemporal spikes (CECTS). Seizure types can include focal seizures, generalised seizures (Atonic seizures, Atypical absence seizures, Myoclonic seizures Generalised tonic-clonic seizures). Some children with GRIN2A-related disorders may develop different types of seizures, which may be difficult to control with anti-seizure medications.
  
  
• Speech difficulties which fall along a spectrum of severity, including speech delay; impairment in conversational speech and language, such as atypical intonation or speech articulation errors; dysarthria and speech apraxia; delays and regression in speech and language development.
  
  
• While some individuals will have neuro-typical development and intellect, others will have a degree of developmental delay and cognitive impairment ranging from mild to severe, including delays in achieving developmental milestones during infancy or early childhood, particularly in speech and language domains.
  
  
• Muscular hypotonia (decreased muscle tone)
  
  
• Movement disorders, including ataxia, dystonia or chorea
  
  
• Behaviour disorders, including aggression, hyperactivity (Attention deficit hyperactivity disorder (ADHD)) or features of autism spectrum disorder
  
  
• Sleep difficulties